tlr2 antagonist c29 Search Results


tlr2 antagonist c29  (Chemdiv Inc)
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Chemdiv Inc tlr2 antagonist c29
a Schematic representation of <t>TLR2</t> signaling, ligand priority and contact point of the two antagonists CU-CPT22 and <t>C29.</t> b HEK293 TLR2/1 or 2/6 reporter cells were stimulated with the indicated concentrations (ng/ml) of Pam 3 CSK 4 or Pam CSK 4 . Dashed lines represent the six time points that were used to generate concentration-effect curves ( c ). Baseline-corrected DMR recordings are mean + SEM and representative of three biologically independent experiments. c Sigmoidal concentration-effect curves resulting from DMR traces of n biologically independent experiments ( c : n = 3 biological replicates except Pam 3 CSK 4 log 3, log 2, log 1 n = 5, Pam CSK 4 log 0, 50 min n = 2) (Mean ± SEM). Concentration-effect curves of DMR data were generated by the response at six different time points ( b ). d HEK293 TLR2 reporter cells were stimulated with the indicated concentrations (ng/ml) of Pam 3 CSK 4 or Pam CSK 4 . HEK293 TLR2/1 or 2/6 reporter cells were preincubated with 50 µM of the TLR2 antagonist ( e ) CU-CPT22 or ( f ) C29 stimulated with the indicated concentrations (ng/ml) of Pam 3 CSK 4 or Pam CSK 4 . Calculated pharmacological parameters of the concentration-effect curves ( c ) are depicted in Table . Baseline-corrected DMR recordings are mean + SEM and representative of three biologically independent experiments. Source data are provided as a Source Data file. ( a ) was created in BioRender. Weindl, G. (2024) BioRender.com/q83w265.
Tlr2 Antagonist C29, supplied by Chemdiv Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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a Schematic representation of TLR2 signaling, ligand priority and contact point of the two antagonists CU-CPT22 and C29. b HEK293 TLR2/1 or 2/6 reporter cells were stimulated with the indicated concentrations (ng/ml) of Pam 3 CSK 4 or Pam CSK 4 . Dashed lines represent the six time points that were used to generate concentration-effect curves ( c ). Baseline-corrected DMR recordings are mean + SEM and representative of three biologically independent experiments. c Sigmoidal concentration-effect curves resulting from DMR traces of n biologically independent experiments ( c : n = 3 biological replicates except Pam 3 CSK 4 log 3, log 2, log 1 n = 5, Pam CSK 4 log 0, 50 min n = 2) (Mean ± SEM). Concentration-effect curves of DMR data were generated by the response at six different time points ( b ). d HEK293 TLR2 reporter cells were stimulated with the indicated concentrations (ng/ml) of Pam 3 CSK 4 or Pam CSK 4 . HEK293 TLR2/1 or 2/6 reporter cells were preincubated with 50 µM of the TLR2 antagonist ( e ) CU-CPT22 or ( f ) C29 stimulated with the indicated concentrations (ng/ml) of Pam 3 CSK 4 or Pam CSK 4 . Calculated pharmacological parameters of the concentration-effect curves ( c ) are depicted in Table . Baseline-corrected DMR recordings are mean + SEM and representative of three biologically independent experiments. Source data are provided as a Source Data file. ( a ) was created in BioRender. Weindl, G. (2024) BioRender.com/q83w265.

Journal: Nature Communications

Article Title: Label-free biosensor assay decodes the dynamics of Toll-like receptor signaling

doi: 10.1038/s41467-024-53770-9

Figure Lengend Snippet: a Schematic representation of TLR2 signaling, ligand priority and contact point of the two antagonists CU-CPT22 and C29. b HEK293 TLR2/1 or 2/6 reporter cells were stimulated with the indicated concentrations (ng/ml) of Pam 3 CSK 4 or Pam CSK 4 . Dashed lines represent the six time points that were used to generate concentration-effect curves ( c ). Baseline-corrected DMR recordings are mean + SEM and representative of three biologically independent experiments. c Sigmoidal concentration-effect curves resulting from DMR traces of n biologically independent experiments ( c : n = 3 biological replicates except Pam 3 CSK 4 log 3, log 2, log 1 n = 5, Pam CSK 4 log 0, 50 min n = 2) (Mean ± SEM). Concentration-effect curves of DMR data were generated by the response at six different time points ( b ). d HEK293 TLR2 reporter cells were stimulated with the indicated concentrations (ng/ml) of Pam 3 CSK 4 or Pam CSK 4 . HEK293 TLR2/1 or 2/6 reporter cells were preincubated with 50 µM of the TLR2 antagonist ( e ) CU-CPT22 or ( f ) C29 stimulated with the indicated concentrations (ng/ml) of Pam 3 CSK 4 or Pam CSK 4 . Calculated pharmacological parameters of the concentration-effect curves ( c ) are depicted in Table . Baseline-corrected DMR recordings are mean + SEM and representative of three biologically independent experiments. Source data are provided as a Source Data file. ( a ) was created in BioRender. Weindl, G. (2024) BioRender.com/q83w265.

Article Snippet: The TLR2 antagonist C29 was obtained from ChemDiv (San Diego, USA).

Techniques: Concentration Assay, Generated

Pharmacological parameters of Pam 3 CSK 4 - and Pam 2 CSK 4 -induced DMR at six selected time points in HEK293 TLR2/1 and TLR2/6 reporter cells

Journal: Nature Communications

Article Title: Label-free biosensor assay decodes the dynamics of Toll-like receptor signaling

doi: 10.1038/s41467-024-53770-9

Figure Lengend Snippet: Pharmacological parameters of Pam 3 CSK 4 - and Pam 2 CSK 4 -induced DMR at six selected time points in HEK293 TLR2/1 and TLR2/6 reporter cells

Article Snippet: The TLR2 antagonist C29 was obtained from ChemDiv (San Diego, USA).

Techniques:

a HaCaT cells were stimulated with LPS E. coli (1000 ng/ml), Pam 3 CSK 4 (1000 ng/ml) or Pam 2 CSK 4 (1000 ng/ml). b HEK293 TLR2/1 reporter cells were stimulated with Pam 3 CSK 4 (100 ng/ml) or Pam 2 CSK 4 (100 ng/ml). c HaCaT cells were preincubated with 50 µM of the TLR2 antagonists CU-CPT22 or C29 stimulated with Pam 3 CSK 4 (1000 ng/ml). Baseline-corrected DMR recordings are mean + SEM and representative of three biologically independent experiments. Source data are provided as a Source Data file.

Journal: Nature Communications

Article Title: Label-free biosensor assay decodes the dynamics of Toll-like receptor signaling

doi: 10.1038/s41467-024-53770-9

Figure Lengend Snippet: a HaCaT cells were stimulated with LPS E. coli (1000 ng/ml), Pam 3 CSK 4 (1000 ng/ml) or Pam 2 CSK 4 (1000 ng/ml). b HEK293 TLR2/1 reporter cells were stimulated with Pam 3 CSK 4 (100 ng/ml) or Pam 2 CSK 4 (100 ng/ml). c HaCaT cells were preincubated with 50 µM of the TLR2 antagonists CU-CPT22 or C29 stimulated with Pam 3 CSK 4 (1000 ng/ml). Baseline-corrected DMR recordings are mean + SEM and representative of three biologically independent experiments. Source data are provided as a Source Data file.

Article Snippet: The TLR2 antagonist C29 was obtained from ChemDiv (San Diego, USA).

Techniques: